Tommy Novak had two goals and an assist, and Kevin Lankinen made 30 saves for the Predators (39-30-8), who were coming off a 5-1 loss at the Dallas Stars on Monday.
Nashville moved three points back of the Winnipeg Jets for the second wild card into the Stanley Cup Playoffs from the Western Conference. Each team has five games remaining.
"We know we have to win a lot of hockey games to stay in it," Novak said. "We've done a pretty god job so far, so hopefully we can keep it going. We've kind of had that mindset for a while now."
Alex Pietrangelo scored two goals, and Jonathan Quick made 24 saves for the Golden Knights (48-22-8), who won their previous two games.
Vegas is in first place in the Pacific Division, three points ahead of the Edmonton Oilers and four ahead of the Los Angeles Kings. Edmonton defeated Los Angeles 3-1 on Monday.
"Not the outcome we wanted, but [we had] chances. Their goalie played awesome," Golden Knights forward Chandler Stephenson said. "He did what he's supposed to. We couldn't beat him for a while. A lot of saves that probably should have been goals, but he made good saves."