Vrana capped a comeback for the Capitals in a matchup of the past two Stanley Cup champions. He skated from the top of the right face-off circle into the left circle and scored on a wrist shot inside the far post.
"That was good patience from our zone," Vrana said. "We really waited for the best shot to take, and then we were there for a long time, so I felt like I could use my skating and shoot the puck, so it was a good job of all three of us (John Carlson, T.J. Oshie)."
WATCH: [All Capitals vs. Blues highlights]
Alex Ovechkin scored his 11th goal in his 15th NHL season opener, Dmitry Orlov scored, Lars Eller had two assists, and Braden Holtby made 20 saves for Washington.
Sammy Blais and Alex Pietrangelo scored, Ryan O'Reilly had two assists, Justin Faulk had an assist in his Blues debut, and Jordan Binnington made 31 saves.
"You never like to give up a lead, let alone a 2-0 lead," Binnington said. "But you know, we've just got to keep working and just stick to the game plan and have a little bit more tenacity, I guess. I think it'll come. It was game one, a lot of emotions tonight. Not the right outcome, and hopefully we will get back at it next game."