Lowry gave Winnipeg a 1-0 lead at 3:53 of the first period, scoring into an open net after Nino Niederreiter's spinning shot in the slot deflected off Jake Middleton to him in the bottom of the left face-off circle.
Scheifele made it 2-0 at 13:10. Nate Schmidt's initial shot was saved by Fleury, but the rebound deflected to the right post, where Scheifele batted it forward and into another open net.
"I play with some really good players that get me the puck in good situations," said Scheifele, who has scored 42 goals this season. "Just got to keep it going."
Minnesota outshot Winnipeg 12-4 in the first.
"Yeah, we got two really bad bounces for the first two goals, right? They had four shots and two goals," Wild coach Dean Evason said. "We had to start behind the eight ball, but we competed and we played right. We didn't catch a couple of bounces, but we had lots of real good opportunities. We played a real strong game. They did. It was a good hockey game."