Hornqvist left Tuesday's contest in the first period after getting hit with a shot and did not return. Galchenyuk's issue has been lingering.
Hornqvist and Galchenyuk join centers Evgeni Malkin and Nick Bjugstad, both lower-body, and Bryan Rust (upper-body) on the injury list. Malkin, Bjugstad and Rust are out longer-term. Pittsburgh is currently without five forwards at its disposal.
Pittsburgh had 10 healthy forwards at Wednesday's practice. The Penguins host Anaheim on Thursday night at PPG Paints Arena at 7 p.m.
