Sidney Crosby has been placed on injured reserve.
Blandisi, 25, appeared in seven games for Pittsburgh after his first recall on October 11, tallying two points (1G-1A).
The Markham, Ontario native has skated in eight games for the WBS Penguins this season, recording four points (2G-2A).
Blandisi has played in parts of four seasons in the NHL, compiling 28 points (9G-19A) in 87 games while hitting career highs during his rookie season in 2015-16 with New Jersey in games played (41), goals (5), assists (12) and points (17).
In parts of four seasons in the AHL with Albany, San Diego, Binghamton and WBS, Blandisi has totaled 124 points (44G-80A) in 166 games while also being named an AHL All-Star in '16-17 while with Albany.
The Penguins take on the Toronto Maple Leafs at 7 p.m. tonight for "Hockey Fights Cancer" night at PPG Paints Arena. Penguins players will wear commemorative black-and-lavender jerseys in the pre-game warmup and also will use lavender tape on their sticks. The jerseys and sticks will then be auctioned off with proceeds benefiting the UPMC Hillman Cancer Center and the Mario Lemieux Foundation.