This marks the first postseason matchup between the teams since 2012, when the Flyers defeated the Penguins in six games during the Eastern Conference Quarterfinals.
The Penguins finished second in the Metropolitan Division with a 47-29-6 record for 100 points, and clinched home-ice advantage with their 4-0 win over Ottawa on Friday.
Philadelphia finished third with a 42-26-14 record for 98 points after clinching with a 5-0 win against the New York Rangers and losses by the Columbus Blue Jackets and New Jersey Devils on Saturday.
Pittsburgh went 4-0 during the regular season against the Flyers. That was the first time since 2006-07 (8-0) that the Penguins swept the regular-season series. Sidney Crosby led the Penguins with nine points (2G-7A) while Claude Giroux (0G-4A) and Jordan Weal (2G-2A) each had four points for the Flyers.
The Penguins scored five goals in all four games versus the Flyers this season, two of which were 5-4 overtime wins on Oct. 27 and March 25 at PPG Paints Arena. In the series against the Flyers, the Penguins went 5 for 13 (38.5%) on the power play, while the Flyers were 2 for 16 (12.5%).