Launched in 2014, his CARES Foundation, which stands for Cancer Alliance for Research, Education and Survivorship, seeks to be a neutral convener between organizations, researchers, academic scientists, drug developers and others to advance new treatments.
With fundraisers like the one that will take place at Bridgestone Arena on Sunday, Hamilton believes the day when they'll no longer be needed is on the horizon.
"I'm here as a product of chemotherapy, and I can't wait until it no longer exists," Hamilton said. "I'm not being hypocritical - I'm grateful that I had a treatment option - but I know that the way I was treated in a matter of years will be so outdated if we all come together and fund the research that made that possible… Now, the science is light years ahead of the money, so we really need to make a difference in that regard."
Make no mistake about it - the show about to take place in the coming days is unlike anything else in the world, and the tangible impact it could have toward the greater good is worth the price of admission in itself.
Throw in some of the biggest stars in the music and skating worlds, and it's exactly the kind of celebration one might expect from a man with an infectious aura of positivity.
That's just what Hamilton does.
"As we're able to fund research, now we have people that can stand up and say, 'Due to the money raised here, at this event and with the research that it funded, I'm alive - and not only am alive, but I have a much better quality of life,'" Hamilton explained. "I'm excited about how far we've come, and the people that have partnered with us and the fact that that continues to grow as well.
"And we're just getting started."