The defeat snapped the Rangers' four-game winning streak against the Sabres and sent the Blueshirts to 0-2 on the young season, with the back end of the weekend road trip coming Sunday night in Carolina.
"There's a difference between playing well and playing winning hockey," head coach David Quinn said. "We did a lot of good things, better than we did the other night. At the end of the day, this is a game of taking advantage of your opportunities, and they took advantage of two of theirs and we only took advantage of one of ours."
Seventeen of the Rangers' 18 skaters put pucks on Hutton in the game; 14 players had multiple shots on goal, led my Mika Zibanejad's eight in 23:04 of ice time. And it started early: The visitors had 12 of the game's first 15 shots on net and were pressing for the opening goal until, with the teams skating 4-on-4, a neutral-zone penalty on Chris Kreider changed the complexion of the game.
Kreider was called for holding Jeff Skinner near the Buffalo blue line on a play in which it looked like Skinner was the one who had grabbed Kreider and dragged him to the ice.
"Looked like? It definitely (should have gone) the other way," Quinn said, adding with a shrug: "What are you going to do? Got to kill a penalty."
Instead, Buffalo opened the scoring on the ensuing power play, when the Rangers were caught in an odd-man rush - a bugaboo from their season opener - and Sheary finished the 2-on-1 himself with a wrist shot from the left hashmarks, the Sabres' first goal of the season and Sheary's first as a Sabre.
Sheary picked up his second goal on a power play 1:42 into the second period, at the end of a pretty passing play from Eichel and Sam Reinhart.
Howden, meanwhile, nearly had his first NHL goal in the second period, when a Buffalo turnover sprung the Rangers on a 3-on-0 rush that ended with Hutton flashing his catching glove to rob the Ranger rookie.