53 Jeff Skinner - 27 Curtis Lazar - 15 Riley Sheahan
Skinner is looking to rebound from a season in which he scored 14 goals in 59 games despite generating 5-on-5 scoring chances at a rate that placed him alongside some of the game's premier forwards.
Krueger spoke highly of his offseason conversations with Skinner and said the forward has worked hard to find his game within the team's principles away from the puck. Once he does, his presence gives any line a natural scoring threat around the net.
"He's worked hard in the offseason," Krueger said. "He's coming in here and for us, what's important no matter your role, no matter your skill level is that in general you play within the principles. He's continuing to work on that together with the coaching staff.
"I think once he lets that go and relaxes and trusts his instincts, he's going to give us what we need, which is we need scoring right through the lineup, and the present setup will give that line opportunity to add to our offense. And it'll be important for Jeff to just keep working hard."
Lazar carved out a consistent role with the Sabres after beginning last season in Rochester, establishing himself as a physical checking presence at 5-on-5 who also killed penalties and took high-pressure faceoffs, including at the start of overtime.
The Sabres had a positive share of shot attempts (51.06) in 82:46 with Skinner and Lazar on the ice together at 5-on-5 last season, according to Natural Stat Trick.
Rounding out the line on Thursday was Sheahan, who arrived at camp on a professional tryout but earned a one-year contract following an injury to Zemgus Girgensons. Read more about his "specialist role" here.
13 Tobias Rieder - 20 Cody Eakin - 24 Dylan Cozens
This line was originally constructed to have a similar personality to the trio of Girgensons, Johan Larsson, and Okposo last season. That group grinded out long shifts in the offensive zone, often setting the table for Buffalo's scoring lines.
"Our job will be to provide energy, to be safe, to be reliable," Eakin said. "Chip in and just be steady."
Eakin replaces Larsson, who signed with Arizona during the offseason. The Sabres like Eakin for his physical style along with his potential for offense, just one season removed from a 22-goal, 41-point campaign with Vegas in 2018-19.
Injuries have changed the makeup of the line, which began with Eakin centering Girgensons and Okposo. Girgensons is expected to miss six months after having surgery to repair a groin injury. Okposo is day-to-day entering the regular season.
Replacing Girgensons is Rieder, another newcomer who the Sabres value for his ability on the penalty kill and his defensively responsible game at 5-on-5. Krueger has also expressed belief that Rieder can contribute offensively in the right situation. (The precedent is Girgensons, who scored his highest goal and point totals since 2014-15 in his first year under Krueger.)
In Okposo's place, it appears the nod willgo to the 19-year-old Cozens in what will be his NHL debut. Cozens was a late entrant to camp after dominating the World Junior Championship with 16 points (8+8) in seven games.
"We definitely trust him," Krueger said. "I mean, he's a very responsible player, extremely smart and coachable. … We think he's ready for a pretty big load off the hop, but only time will tell for all of us."