The Sabres tweaked their units after the 0-for-6 night on Tuesday, promoting Dylan Cozens to the top grouping along with Rasmus Dahlin, Sam Reinhart, Casey Mittelstadt, and Victor Olofsson.
Interim head coach Don Granato said he saw intricacies to build off with that look but felt frustration threw the power play off its game early.
"We had five power plays, I believe," Granato said. "We allowed ourselves to get frustrated partway through the first one. … And then that carried over to maybe squeezing our sticks tight the rest of the way."
The Sabres finished with a combined five shots on goal over the course of their five opportunities.
"It's no secret how guys score goals on the power play," Mittelstadt said. "You look at the other teams and you look at a team like Boston - in the playoffs, good power play - they snap it around and when they see the shot, they got a guy in front and fire it and go get it back and do it again.
"Eventually, if you keep getting it back, you're going to find seam or find someone open. Yeah, that's another part of it, for sure. There's some things we got to work on with that."