The Sabres began to retreat to some bad habits, and their third forward pinching too low resulted in back-to-back goals on the rush for Seth Jones and Nick Foligno. On the first of those two plays, O'Reilly said it was a missed check on his behalf that led to Columbus having numbers going back the other way.
"I missed that [breakaway] and get a little frustrated and I make a mistake offensively too," O'Reilly said. "I missed my check on the forecheck and he beats me back up ice and they score a goal."
Matt Calvert scored to extend the Columbus lead to 4-0 prior to the end of the period, tipping a shot between the pads of Chad Johnson and going behind the goalie to tip the puck past the line.
Playing their second game in as many nights, the Sabres struggled to mount any sort of comeback in the third. They didn't get their first goal until Seth Griffith scored with 2:34 remaining, and even then Josh Anderson answered with a goal for the Blue Jackets.
"Once we got down, you could just feel we didn't have the gas," O'Reilly said. "We started fighting it, we tensed up, we just couldn't get anything going after that."
Bobrovsky, the reigning Vezina Trophy winner, was his usual self in a 34-save performance. He kept the Sabres at bay when they generated chances through the first two periods, but Housley felt his team didn't do itself any favors with its lack of a net-front presence.
Aside from that, the Sabres thought they had executed their game plan well up until the three-goal stretch at the end of the second. By the end of the first period, they held a 22-17 advantage in shot attempts.
The one goal they did allow in the first came from Oliver Bjorkstrand on the power play, with Johnson heavily screened. He made 33 saves on 38 shots.
"You can't fault chad on anything tonight," Housley said. "He played really strong, we just didn't protect him enough."
The loss snaps a streak of two consecutive wins for the Sabres, who are continuing to learn lessons the hard way so far in the young season. In Columbus, that lesson traced back to the O'Reilly breakaway and the way they responded.
"Good teams, they don't beat themselves and they don't crack," Housley said. "Even being down one, we were still playing well. We shouldn't have gotten away from our game plan. Because of it, we get a little cheat in our game and then it winds up in our net."