Alex Tuch scored his career-high 21st goal of the season to end Sergei Bobrovsky's shutout in the third period, but the Sabres fell 4-1 to the Florida Panthers inside KeyBank Center on Monday.
Brandon Montour, Sam Bennett, Anton Lundell and Carter Verhaeghe scored goals for the Panthers. Bobrovsky allowed one goal on 29 shots.
The Panthers pulled ahead on Montour's goal just 4:01 into the game and led from that point on.
"We just didn't quite start on time today," Sabres captain Kyle Okposo said. "They, obviously, had some jump. It's a big game, and they knew it right away, and they came out and they jumped on us. When we realized we were in a fight, it was a little too late."
Ukko-Pekka Luukkonen made 30 saves for Buffalo.
Postgame Report | Sabres fall short in home loss to Florida
Buffalo drops 4-1 decision Monday afternoon at KeyBank Center