Colorado answered back on their second power play of the night as Mikko Rantanen found Nazem Kadri with a cross-ice feed that he put past Robin Lehner at 6:53 of the first.
Kadri added his second of the game just minutes later off the rush as the trailer in the high slot, receiving a pass from Matt Nieto that he buried for a 2-0 lead at 9:18.
Nathan MacKinnon would find the net from a similar position at 11:08 of the opening frame for a 3-1 lead heading into the first intermission for the second consecutive game.
The second period started off on the wrong foot as Colorado struck soon after returning to full strength with Joonas Donskoi finding the back of the net off the rush into the Blackhawks end at 2:52.
From there, things continued to trend Colorado's way. Mikko Rantanen scored in his first game back from injury at 5:50 of the middle frame, putting home a rebound off a Samuel Girard wrist shot. Donskoi then added his second of the night at 8:28 for a 6-1 lead before Tyson Jost made it 7-1 at 10:36.
Chicago broke the Avalanche onslaught as Dominik Kubalik beat Philippe Grubauer five hole after David Kampf paid the price off the rush to find Kubalik for the goal at 11:14 of the second to make it 7-2.