Danforth made it 1-0 at 8:55 of the first period, getting his own rebound after Gustavsson stopped his initial deflection from point-blank range.
Kent Johnson gave the Blue Jackets a 2-0 lead at 6:10 of the second period. Cole Sillinger won the face-off from the right dot back to Johnson for a one-timer for his first goal of the season.
Mermis responded at 7:21 to cut it to 2-1 with a snap shot through traffic.
Mats Zuccarello tied it 2-2 just 54 seconds later at 8:15 with a snap shot following a backhand pass from Ryan Hartman. It was his first goal of the season.
Columbus outshot Minnesota 22-6 in the second period.
“Obviously, [Gustavsson] made some big stops and a lot of stops,” Johansson said. “He played great. It’s up to us to play better in front of him and score more goals if we need to.”
Jonas Brodin scored his first goal of the season at 4:42 of the third period with a shot off Merzilkins’ blocker to give the Wild a 3-2 lead.
Boone Jenner took a backhand pass from Zach Werenski in the slot to make it 3-3 at 7:36.
Zuccarello appeared to put the Wild ahead 4-3 at 11:54, but the Blue Jackets successfully changed Johansson preceded the puck into the offensive zone.
“Anything can happen in OT, but I think it [stinks] that we got that power play goal called off,” Zuccarello said. “And they get a goal right after. We came back, we fought back, but at the end of the day they made it hard for us. And in our zone, we weren’t good enough.”
Jenner had eight shots on goal, five blocked shots and won 17 of 21 face-offs (81 percent) in 22:46 of ice time.
“We thought we were working for our chances with our forecheck, paying to our strengths a little bit more in their zone,” said Jenner, the Blue Jackets captain. “Obviously, some good looks. … We know if we do the right things, the rest is going to come into play.”
NOTES: Fantilli is the second-youngest player in Blue Jackets history to score in his first career road game (Rostislav Klesla, (18 years, 205 days on Oct. 12, 2000). … Columbus forward Johnny Gaudreau had the assist on Roslovic’s goal and has 36 overtime points in his career, which trails Sidney Crosby (43), Alex Ovechkin (38), Evgeni Malkin (38) and Patrik Elias (37) for the most in NHL history. … Zuccarello extended his season-opening point streak to five games for the second time in as many years. He became the first player in Wild history with multiple runs of at least that length.