Pastrnak has missed the last two games after having the olecranon bursa removed from his right elbow. Vatrano, on the other hand, has yet to play this season following surgery to repair torn ligaments in his left ankle just ahead of training camp.
"Either guy could, yeah," Bruins coach Claude Julien said, when asked if the two would play on the trip. "There's no sure shot answer to that. We still have to make sure everything is OK before that happens."
Pastrnak returned to practice for the first time since the procedure on Wednesday morning and appeared unimpeded during the optional session.
"I feel good. The trainers did a good job. I'm back and I feel good," said Pastrnak. "It's always tough to watch games from the top. You want to play and you don't want to spend any time injured. I'm happy I'm back on the ice. I missed two games, it could be worse. Always can be worse, so happy I'm back."
Vatrano was recalled from Providence on Monday after scoring two goals in two games with the P-Bruins (he now has 38 goals in 38 career games in the NHL). The second-year winger did not play against the Islanders on Tuesday, but feels ready to get back in the lineup.
"Anyone who comes back from injury is always excited, whether it's Providence or here," said Vatrano. "I just want to get into as many games as possible. Obviously I wasn't in the lineup [Tuesday] night, but I wouldn't take it as a negative.
"They want me to be read when I'm ready. I want to make sure I'm ready when I step in. I don't want to be rusty at all. I want to make sure I'm up to the challenge when I'm back in the lineup."