The Flames won each of the three games against the Avalanche this season, outscoring them 14-10, including scoring 11 goals in the final two games.
It is the first time the teams have met in the postseason.
Mark Giordano, who finished second in the NHL in scoring among defensemen with 74 points (17 goals, 57 assists), led Calgary with seven points (one goal, six assists) and forward Elias Lindholm scored in each of the three games against Colorado. David Rittich started two games for the Flames, allowing five goals on 61 shots (.918 save percentage). Veteran Mike Smith made 21 saves in a 6-5 victory Nov. 1.
"We have a talented group up and down the lineup. We've got some great depth, we've got some stars, some great goaltending, great D, great forwards," Harmonic said. "We've got a really good team. We are super excited to get going."
Forward Gabriel Landeskog led Colorado with four points (one goal, three assists) in three games against Calgary, and Nathan MacKinnon had two goals. Semyon Varlamov started each of the three games, going 0-2-1 with a 4.44 goals-against average and an .860 save percentage.
"They are a great team and they are going to be a huge challenge," Avalanche defenseman Ian Cole said. "They are very dangerous and we need to be on our toes every shift."
The last time the Flames finished first in the Western Conference was 1988-89 (won Stanley Cup).