MacKinnon has three straight multipoint games (two goals, five assists).
Samuel Girard had one goal and one assist for the Avalanche (2-1-0). Alexandar Georgiev made 36 saves.
"I thought [Georgiev] was really good again," Colorado coach Jared Bednar said. "You look at the goals he's given up so far this season, it's all power play and one with a delayed penalty with the goalie pulled. Five-on-5, he's been strong. It seems like he's reading where the chances are coming from. He's been early getting over into position and making some nice saves. I thought both goalies played really well at the end of the game. There was a couple flurries at both ends, but 'Georgie' made the big four saves on that one scrum which kind of keeps us with our lead."
Kirill Kaprizov scored twice, and Calen Addison had three assists for Minnesota (0-3-0), which has not had a lead this season. Filip Gustavsson made 32 saves.
The Wild have allowed at least six goals in all three games and have been outscored 20-12.
"Goals against is a concern," coach Dean Evason said. "It's not on the goalie. It's on the goalie, it's on the defense, it's on the forwards, it's on the coaches. It's on all of us. We're giving up way too many goals. … We'll all be accountable, and we'll get rid of this together."