Carter Verhaeghe pushed the Florida lead to 3-1 on the power play at 19:32 with a snap shot from the left circle.
Eriksson Ek cut it to 3-2 at 4:37 of the third period with a power-play goal on the doorstep.
"We actually liked our game pretty much the whole night," Wild coach Dean Evason said. "Obviously we didn't get the results, and we didn't score enough. … [At] 5-on-5 here tonight we didn't find a way to score. … If you're not scoring, you've got to continually work at keeping it out of our net, and we didn't here tonight."
Gustav Forsling extended the lead to 4-2 at 7:51 after getting to a loose puck in the slot.
With Gustavsson pulled for the extra attacker, Spurgeon made it 4-3 at 18:34, but Reinhart scored into an empty net at 19:21 for the 5-3 final.
Minnesota went 2-for-2 on the power play. Florida was 1-for-2.
"That's our job is to go out there and be game-changers," Addison said of the power play. "When it's not clicking … it can cost us or take some of the momentum, confidence away from our team. I think our job is to go out there and know what our task at hand is."
Panthers defenseman Aaron Ekblad did not play after the first period because of an upper-body injury, and Florida forward Sam Bennett left midway through the second period with an upper-body injury. Maurice said each could play in the next game, at the New York Rangers on Monday.
"A lot of guys went down today," Lyon said. "To me, these are the kind of games you play for. So many guys digging in, playing with five defensemen, massive points on the line. To me, this is fun, and this is where you get to test your true mettle."
NOTES: Wild forward Marcus Foligno did not play because of a non-COVID-related illness. … Bobrovsky did not dress and is expected to be out for the next two games. … Florida also was without forward Eric Staal, who entered NHL concussion protocol following a hit from Canadiens defenseman Mike Matheson on Thursday and is expected to be sidelined for at least two more games. … Luostarinen scored his 10th goal of the season, setting an NHL career high in his 48th game. He scored nine in 78 games last season.