The play started after Blue Jackets forward Kirill Marchenko turned the puck over at the offensive blue line.
"He's coming over the wall, and he's got Johnny (Gaudreau) to his left, and it's the right play," Columbus coach Brad Larsen said. "If he lays it over there, Johnny probably gets to the bottom of the circle, and maybe we win the game. But you've got to make the play.
"That's the one thing we talked about right from the first period on, you don't get pucks through the neutral zone and through passing to the corner to the top of their circles. They're just deadly. They're so quick in transition that you have to be so careful."
Yegor Sharangovich and Jesper Bratt also scored, and Vitek Vanecek made 31 saves for the Devils (35-13-5), who extended their point streak to five games (4-0-1) and are 11-1-2 in their past 14.
Adam Boqvist had a goal and an assist, and Merzlikins made 29 saves for the Blue Jackets (16-34-4), who have lost five of six (1-4-1).
"Zero problem with the effort. I thought we played excellent," Larsen said. "The third period it got a little away from us as far as turnovers, the puck management, but we still only had three chances against until that goal.
"It's disappointing we lost. You can look at a lot of positive signs against a high-end team in the NHL."