Eriksson Ek cut it to 4-3 at 11:23, scoring off the rush for a short-handed goal.
Brock McGinn made it 5-3 at 14:43 with a wrist shot off a turnover by Wild forward Mats Zuccarello, and Guentzel scored an empty-net goal to make it 6-3 at 16:31.
"Obviously, we're not scoring enough goals," Minnesota coach Dean Evason said. "You can look at four, but we had opportunities, probably, to score earlier and didn't. First period we're down. We actually played a good period, but we battled. We clawed. We got back in the game and obviously, we didn't do enough as a group to get it done."
Matt Dumba scored with eight seconds remaining on a one-timer from the left circle for the 6-4 final.
"We've got a lot of new guys in the lineup and we have to find our identity and play the whole way 60 minutes and that's how we have to win games," Foligno said. "We've got to win games 2-1. It's gonna be ugly. We don't have the firepower that we thought we did. ... We need guys to step up. I just feel like we've got to find our identity of becoming [a team] that wins tight games."
NOTES:Wild forwards Kirill Kaprizov (six points; two goals, four assists) and Zuccarello (five points; one goal, four assists) each extended his point streak to five games. … Crosby scored his 100th career game-opening goal, becoming the second active NHL player to reach the mark (Alex Ovechkin of the Washington Capitals, 134), and tied Mario Lemieux for the most in Penguins history. He passed Gordie Howe for the 10th-most three-point games in NHL history (163) and is one behind Jari Kurri. ... Minnesota forward Tyson Jost had 7:54 of ice time after being a healthy scratch for three games.