The Senators had a few more scoring chances late in the second period, but the game entered the third with the Rangers holding a 2-0 lead.
Less than five minutes into the final period. Artemi Panarin scored his 49th of the season and with exactly seven minutes remaining Alexis Lafrenière scored the 4th goal of the game.
"They play the right way, they play hard, they've got skill, they've got depth so when you look over there it should fire you up to play them but we didn't have enough fire tonight," explained Jake Sanderson on facing off against a President's Trophy winning club in the Rangers.
The Senators will head to Boston tonight and close out the season against the Bruins tomorrow night.
"Last game tomorrow, the season hasn't gone the way you want it to, but there are three more periods so we have got to lay it all out there," added Sanderson.
Catch tomorrow's game on TSN5 and RDS2 at 7 p.m. from TD Garden.