Ruzicka continued to be red hot since being put on a line with Elias Lindholm and Tyler Toffoli, scoring his third and fourth goals in his last four games, while also collecting an assist as the Flames won 5-4 in a shootout against the Panthers.
Andersson clinched it in the 1-on-1 battle, the fifth shooter for Calgary. Huberdeau also had a shootout marker as the other Calgary scorer.
For Ruzicka, it was his first career two-goal effort, his first career three-point game, and was his third multi-point game in his last four outings.
He was held off the scoresheet in Thursday's 4-1 loss to the Lightning to start this season-long six-game roadie, but tallied a goal and a helper in the team's previous two wins.
Nikita Zadorov also scored and had an assist, while Blake Coleman tallied in the third period.
Jacob Markstrom made 31 saves, as did Spencer Knight.
The Flames improved to 8-7-2 with the victory while the Panthers fell to 9-8-1.
Huberdeau and Weegar were the last two players to leave the ice for Calgary after warmups, both receiving a standing O from the fans that had already settled into the bowl.
Later in the first period, a tribute video was played with a 'Thank You' message to both players at the end, once again bringing the fans out of their seats with loud applause.
Panthers captain Aleksander Barkov returned to the lineup after missing the previous game against the Stars due to illness, which led Florida to play with only 17 skaters in that tilt.
Florida went to the powerplay at 8:47 when Andrew Mangiapane was called for hooking Tkachuk during a lengthy Florida cycle in the Calgary zone.
Calgary killed it off and not long after, Dillon Dube had a glorious chance to open the scoring but his one-timer went off the post.
Ruzicka opened the scoring with 4:47 to go in the period on the powerplay, getting the puck in the left faceoff circle from Noah Hanifin and snapping a wrister past Knight.