It's a quick turnaround for the Flames, as they headed right to the airport to board a plane for Seattle where they face the Kraken Friday night.
After that, the team has a bye week through the all-star festivities next weekend in South Florida.
Jonathan Huberdeau scored the lone marker for the Flames - an absolute beauty - while Jacob Markstrom was excellent making 24 saves, especially early to keep his side in it.
Jaxson Stauber stopped 34 pucks for Chicago.
The Flames outshot the Blackhawks 18-6 in the third period but couldn't find twine.
Head coach Darryl Sutter threw the lines in a blender during the game, going with a handful of different combinations - including having youngster Jakob Pelletier play with Huberdeau and Nazem Kadri. The trio had some great chances as the night wore on.
Chris Tanev missed the game due to injury, while Connor Mackey drew into the lineup.
Meanwhile, Chicago captain Jonathan Toews sat out with with non-Covid illness.
Markstrom made an absolutely massive stop early in the game less than two minutes in, kicking out his right leg to deny Colin Blackwell, who walked in all alone and threw a few moves.
The Flames 'tender later stood tall to deny Reese Johnson on a partial breakaway.
Taylor Raddysh opened the scoring, beating Markstrom shortside with 2:13 to play, but Huberdeau answered back with just 28 ticks left in the frame.
Kadri drove into the zone, passing to Huberdeau as he came down the middle, toe-dragged around Jake McCabe leaving the defenceman on his knees, then going backhand-forehand in tight to put it around Stauber for No. 10's 10th of the season.
It was a 'goal-of-the-year' candidate, with MacKenzie Weegar getting the other apple.
