Buffalo is coming off a 6-5 overtime loss to the Tampa Bay Lightning on Monday. The Sabres led, 5-3, midway through the third period but allowed three unanswered goals, dropping to 2-9-1 in their past 12 games.
Tage Thompson, who recorded a hat trick and three assists in his last outing against the Red Wings, paces Buffalo and is tied for 10th in the NHL in scoring with 28 points (14 goals, 14 assists). Jeff Skinner (10-12-22) has five goals and three assists in the past five games, while Sabres netminder Craig Anderson is 4-4-0 with a 2.76 goals-against average.
Wednesday's game is the second of four meetings this season between the two clubs. Buffalo defeated Detroit, 8-3, at KeyBank Center on Oct. 31.